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A 45-year-old male presents to the hematology clinic with symptoms of progressive fatigue,
frequent bruising, and recurrent nosebleeds over the past few weeks. On physical examination,
he appears pale and has petechiae on his lower extremities. Blood tests reveal a white blood cell
count of 50,000/mm³ with 60% blasts, hemoglobin of 8.5 g/dL, and platelets of 25,000/mm³. A
bone marrow biopsy confirms the diagnosis of AML, showing hypercellularity with 70%
myeloblasts. Cytogenetic analysis reveals a FLT3-ITD mutation, placing him in the intermediate-
risk category.
In 1 -2 pages, answer the questions below in detail. You must use current evidence-based
resources to support your answers. Follow APA guidelines. Follow the grading rubric.
Questions:
1. 2. 3. 4. 5. 6. 7. What is the primary cellular abnormality in AML?
How does the accumulation of leukemic blasts affect normal hematopoiesis?
What role do genetic mutations play in the development of AML?
Why do patients with AML often present with symptoms like fatigue, infections, and
bleeding?
What is the significance of Auer rods in the diagnosis of AML?
What is the impact of AML on the immune system?
How do treatment strategies target the pathophysiological mechanisms of AML
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