Category: Sickle Cell Anemia

Sickle Cell Anemia: A Succinct Look Into Recently Tested Disease Modifying Interventions Oxidative Stress and Vascular Tone The aberrant biochemistry of SCA promotes premature intravascular hemolysis. This occurs when sickled red cells release free hemoglobin polymers into the blood plasma via the free hemoglobin scavenging mechanism. This consequentially impairs the synthesis and circulation of nitric…

The Peculiarities Of Sickle Cell Disease Introduction Haemoglobin is a word that was coined from two words haemo which means blood and globin meaning protein. Globin is a protein substance of four different polypeptide chains that have (141-146)amino acids. Haemoglobin is a conjugated globular protein. There are two important oxygenbinding proteins in vertebrates namely haemoglobin…

The Peculiarities Of Sickle Cell Anemia Sickle cell anemia is severe, chronic and even fatal disease. It causes red blood cells to break down and and sickle (form a crescent shape). It occurs due to a point mutation in the Red blood cells which blocks blood flow therefore there is a chronic deprivation of oxygen…

Treatment Methods For Sickle Cell Disease This disease has impacted my life in so many different ways: good and bad. These are the words from Natasha Thomas, a woman who was diagnosed with sickle cell disease at the age of seven. Sickle cell disease is a blood disorder that affects the red blood cells in…

A Look Into Recently Tested Disease Modifying Interventions Of Sickle Cell Anemia Abstract Sickle cell anemia (SCA) is a globally prevalent, monogenic, life-threatening blood disorder with a complex pathology that remains obscure. A deepened understanding of the malady in the recent years has led to pharmaceutical advancements that target pathophysiology and ultimately ameliorate associated multivariate…

Sickle Cell Anaemia Genetic Basis Sickle Cell Anaemia is an autosomal recessive disorder which is passed through generations; meaning it is a hereditary disease. To inherit Sickle Cell Anaemia an individual must receive a mutated gene from both their paternal and maternal side. Those who only receive one mutated gene are said to be carriers…

A Succinct Look Into Sickle Cell Anemia What is sickle-cell anaemia Sickle-cell anaemia is a hereditary, homozygous, genetic blood disorder that occurs within a person who has abnormal haemoglobin on their red blood cells. The Haemoglobin are sensitive to low amounts of oxygen in the body which makes them transform into sickle or crescent shapes.…