ARA-C)5-fluorouracil (5-FU) ThymidylateSynthase Inhibition Raltitrexed (Tomudex”) Adenosine Deaminase Inhibition Pentostatin (Nipent”) RibonucleotideReductase Inhibition Hydroxycarbamide(Hydrea”) DNA-Interactive Agents Alkylating Agents Dacarbazine Abstract The study of the development of anti-cancer drugs and preclinical toxicity tests has until today encountered a major problem identified as lack of a reliable in vitro-tumor model able to mimic in vivo conditions. These…